Masseyville is located in the 12th Civil Distric and was named for Bill Massey, an early settler. Masseyvill was originally in McNairy County and first settled in 1879. They had an early postoffice which was in the J.H. Mitchell home. Mitchell and Sons also ran the first general store and was known as the "Wheeler Store". J.H. Mitchel practiced medicine, owned a sawmill, a grist mill and a gin.

The founder of West Tennessee Business College was Romas Massey. Ernest Fortune owned a drug store for many years. Earliest known settlers were Elijah Hurst, Andrew Maness, the Massey family, Ed Siler, J.F. Fortune, John Ingle, A.F. Smith * J.L. Robinson.